Biohealth Reviews publishes research papers, and honest reviews of health and beauty products
First Covid-19 vaccine tested in US poised for final trials – The National
Last Updated on July 15, 2020 by
The first coronavirus vaccine tested in the US caused people to produce antibodies in the way scientists have hoped, as the shots are poised to begin final testing.
“No matter how you slice this, this is good news,” Dr Anthony Fauci, the US government’s top infectious disease expert, told AP.
The vaccine, made by US biotech firm Moderna, is due to enter the final stage of human trials for its Covid-19 vaccine on July 27, after promising early results were seen and published in a prominent journal.
The Phase 3 trial will recruit 30,000 volunteers in the US, with half to receive the vaccine at 100 microgram dose levels, and the other half to be given a placebo.
The trial will show whether the vaccine is safe and can prevent infection by the Sars-Cov-2 virus or, if people still get infected, whether it can prevent the infection progressing towards symptoms.
If they do get symptoms, the vaccine can still be considered a success if it stops severe cases of Covid-19.
The study is expected to run until October 27.
The announcement came after the New England Journal of Medicine on Tuesday published results from the first stage of Moderna’s vaccine trial, which showed the first 45 participants all developed antibodies to the virus.
The 45 participants were split into three groups of 15 each to test doses of 25 micrograms, 100 micrograms and 250 micrograms.
They were given a second dose of the same amount 28 days later.
After the first round, antibody levels were found to be higher with higher doses.
After the second round, participants had higher levels of antibodies than most patients who have had Covid-19 and gone on to generate their own antibodies.
Moderna is considered to be in a leading position in the global race to find a vaccine against the coronavirus, which has infected more than 13.2 million people and killed 570,000.
China’s SinoVac is also at Phase 2.
The UAE is also is pushing ahead with efforts to develop two types of Covid-19 vaccine, which are being tested on more than 15,000 volunteers.
It is on the third stage of the clinical trials and if either vaccine is confirmed to be safe and effective, it will move to the manufacturing stage.
Russian news agency Tass on Sunday announced Russian researchers have completed clinical trials on a vaccine, although they have not shared their data.
But scientists caution that the first vaccines to come to market may not be the most effective or safest.